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1

Combinatorial synthesis — the design of compound libraries and their application to drug discovery

Nicholas K. Terrett, Mark Gardner, David W. Gordon, Ryszard J. Kobylecki, John Steele

Journal:

Year:

1995

Language:

english

File:

PDF, 2.30 MB

english, 1995

2

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

Nicholas K. Terrett, Andrew S. Bell, David Brown, Peter Ellis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 326 KB

english, 1996

3

The exploration of macrocycles for drug discovery — an underexploited structural class

Driggers, Edward M., Hale, Stephen P., Lee, Jinbo, Terrett, Nicholas K.

Journal:

Nature Reviews Drug Discovery

Year:

2008

Language:

english

File:

PDF, 856 KB

english, 2008

4

An even pattern of xylan substitution is critical for interaction with cellulose in plant cell walls

Grantham, Nicholas J., Wurman-Rodrich, Joel, Terrett, Oliver M., Lyczakowski, Jan J., Stott, Katherine, Iuga, Dinu, Simmons, Thomas J., Durand-Tardif, Mylene, Brown, Steven. P., Dupree, Ray, Busse-Wic

Journal:

Year:

2017

Language:

english

File:

PDF, 2.55 MB

english, 2017

5

Drug Discovery by Combinatorial Chemistry—the Development of a Novel Method for the Rapid Synthesis of Single Compounds

Nicholas K. Terrett, Mark Gardner, David W. Gordon, Ryszard J. Kobylecki, John Steele

Journal:

Chemistry - A European Journal

Year:

1997

Language:

english

File:

PDF, 676 KB

english, 1997

6

Stereospecific syntheses and reactions of allyl- and allenyl-silanes

Ian Fleming, Nicholas K. Terrett

Journal:

Journal of Organometallic Chemistry

Year:

1984

Language:

english

File:

PDF, 1.38 MB

english, 1984

7

Radical cyclisations of imines and hydrazones

W. Russell Bowman, Peter T. Stephenson, Nicholas K. Terrett, Adrian R. Young

Journal:

Year:

1995

Language:

english

File:

PDF, 1.96 MB

english, 1995

8

The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317

Nicholas K. Terrett, Dejan Bojanic, David Brown, Peter J. Bungay, Mark Gardner, David W. Gordon, Carolyn J. Mayers, John Steele

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 327 KB

english, 1995

9

Parallel-compound synthesis: Methodology for accelerating drug discovery

Christopher N. Selway, Nicholas K. Terrett

Journal:

Bioorganic & Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 946 KB

english, 1996

10

Synthesis of spiroethers using radical cyclisations

Donald S Middleton, Nigel S Simpkins, Michael J Begley, Nicholas K Terrett

Journal:

Year:

1990

Language:

english

File:

PDF, 1.31 MB

english, 1990

11

Radical cyclisations of dienes and enynes using phosphorus- and sulfur-centred radicals

Julie E. Brumwell, Nigel S. Simpkins, Nicholas K. Terrett

Journal:

Year:

1994

Language:

english

File:

PDF, 1.37 MB

english, 1994

12

Cyclisation of carbinyl radicals onto imines and hydrazones

W.Russell Bowman, Peter T. Stephenson, Nicholas K. Terrett, Adrian R. Young

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 325 KB

english, 1994

13

Cyclisation of dienes and enynes using phosphorus-centred radicals

Julie E. Brumwell, Nigel S. Simpkins, Nicholas K. Terrett

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

14

Radical cyclisation of dienes and enynes using TolSO2SePh

Julie E. Brumwell, Nigel S. Simpkins, Nicholas K. Terrett

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 254 KB

english, 1993

15

Facile synthesis of functionalised spiroethers via radical cyclisations

Donald S. Middleton, Nigel S. Simpkins, Nicholas K. Terrett

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 237 KB

english, 1988

16

The stereochemistry of some SE2′ reactions of allyl- and allenylsilanes

Ian Fleming, Nicholas K Terrett

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 198 KB

english, 1983

17

Stereospecificity in the synthesis of allylsilanes from tertiary allylic acetates

Ian Fleming, Nicholas K Terrett

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 101 KB

english, 1983

18

Synthesis of N-protected spiroamines related to natural products using radical cyclisations

Donald S. Middleton, Nigel S. Simpkins, Nicholas K. Terrett

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 246 KB

english, 1989

19

Stereospecific allylsilane reactions: a total synthesis of dihydronepetalactone

Ian Fleming, Nicholas K Terrett

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 146 KB

english, 1984

20

Imidazo[2′-3′-:6,5]dipyrido[3,2-b:2′,3′-e]-1,4-diazepines: non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine

Nicholas T. Terrett, Dejan Bojanic, James R. Merson, Peter T. Stephenson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 459 KB

english, 1992

21

4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK2) receptor

A.Roderick MacKenzie, Allan P. Marchington, Donald S. Middleton, Sandra D. Newman, Christopher N. Selway, Nicholas K. Terrett

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

22

Comparison of algorithms for dissimilarity-based compound selection

Michael Snarey, Nicholas K. Terrett, Peter Willett, David J. Wilton

Journal:

Journal of Molecular Graphics and Modelling

Year:

1997

Language:

english

File:

PDF, 435 KB

english, 1997

23

Methods for the synthesis of macrocycle libraries for drug discovery

Nicholas K. Terrett

Journal:

Drug Discovery Today: Technologies

Year:

2010

Language:

english

File:

PDF, 428 KB

english, 2010

24

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors

Mao, Yongjun, Zhu, Wenxiu, Kong, Xiaoguang, Wang, Zhen, Xie, Hua, Ding, Jian, Terrett, Nicholas Kenneth, Shen, Jingkang, Shen, Jingshan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.66 MB

english, 2013

25

The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA

Wang, Zhen, Zhu, Difeng, Yang, Xiaochun, Li, Jianfeng, Jiang, Xiangrui, Tian, Guanghui, Terrett, Nicholas Kenneth, Jin, Jie, Wu, Honghai, He, Qiaojun, Yang, Bo, Shen, Jingshan

Journal:

The Journal of Sexual Medicine

Year:

2013

Language:

english

File:

PDF, 288 KB

english, 2013

26

Stereocontrol in organic synthesis using silicon-containing compounds. A synthesis of (±)-dihydronepetalactone using the SE2′ reaction of an allylsilane

Fleming, Ian, Terrett, Nicholas K.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

27

DNA-encoded chemical libraries of macrocycles

Connors, William H, Hale, Stephen P, Terrett, Nicholas K

Journal:

Current Opinion in Chemical Biology

Year:

2015

Language:

english

File:

PDF, 960 KB

english, 2015

28

Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer

Zhang, Yong, Seigal, Benjamin A., Terrett, Nicholas K., Talbott, Randy L., Fargnoli, Joseph, Naglich, Joseph G., Chaudhry, Charu, Posy, Shana L., Vuppugalla, Ragini, Cornelius, Georgia, Lei, Ming, Wan

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

29

WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors

Mao, Yongjun, Xie, Kai, Zhu, Wenxiu, Li, Jianfeng, Xie, Hua, Ding, Jian, Terrett, Nicholas Kenneth, Shen, Jingkang, Shen, Jingshan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

File:

PDF, 25 KB

2012

30

The Regiochemistry of the Protodesilylation of Some Cyclopropylmethylsilanes Derived from Allylsilanes

Fleming, Ian, Sanderson, Philip E. J., Terrett, Nicholas K.

Journal:

Year:

1992

File:

PDF, 509 KB

1992